SODIUM DITIOCARB AS ADJUVANT IMMUNOTHERAPY FOR HIGH-RISK BREAST-CANCER - A RANDOMIZED STUDY

被引：77

作者：

DUFOUR, P

LANG, JM

GIRON, C

DUCLOS, B

HAEHNEL, P

JAECK, D

JUNG, JM

OBERLING, F

机构：

[1] CTR RADIOL,F-67000 STRASBOURG,FRANCE

[2] CHU HAUTEPIERRE,SERV CHIRURG DIGEST,F-67098 STRASBOURG,FRANCE

[3] CTR PAUL STRAUSS,F-67000 STRASBOURG,FRANCE

来源：

BIOTHERAPY | 1993年 / 6卷 / 01期

关键词：

ADJUVANT IMMUNOTHERAPY; BREAST CANCER; DITIOCARB SODIUM;

D O I：

10.1007/BF01877380

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sixty-four patients with non metastatic high risk breast cancer were randomized in a double blind trial of adjuvant immunotherapy with sodium ditiocarb (DDC) versus placebo. All patients underwent prior surgery (mammectomy according to Patey) then adjuvant FAC chemotherapy +/- DDC. With a median follow-up of 5 years we observed 6 relapses and 5 deaths in DDC group; 13 relapses and t2 deaths in control group. At 6 years, overall survival is 81% in DDC group versus 55%. Disease free survival (DFS) is 76% in DDC group versus 55%. DDC associated to chemotherapy and locoregional treatment can improve survival and probably DFS in this high risk breast cancer subgroup.

引用

页码：9 / 12

页数：4

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