MALIGNANCY IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A REPORT OF 5 CASES IN A SERIES OF 96 PATIENTS

被引:32
作者
DUPLA, ML
KHAMASHTA, M
GARCIA, VP
URIOL, PL
ORTEGA, EV
AGUADO, AG
机构
[1] LA PAZ HOSP,DEPT MED,MADRID,SPAIN
[2] ST THOMAS HOSP,RAYNE INST,LUPUS ARTHRITIS RES UNIT,LONDON SE1 7EH,ENGLAND
关键词
SLE; NEOPLASIA; IMMUNOSUPPRESSION;
D O I
10.1177/096120339300200608
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The association of systemic lupus erythematosus (SLE) and malignancy has been reported previously and suggests an increased risk of cancer in this disease. Lymphomas are the most frequent neoplasias reported in these patients and carcinoma of the cervix and breast are also seen. Several factors probably play a role in the aetiology of malignancies associated with SLE including intrinsic disturbances of immunity and concomitant immunosuppressive therapy. We report five solid tumors (one breast carcinoma, one squamous cell carcinoma of the anus, one adenocarcinoma of the rectum, one carcinoma of the cervix and one carcinoma of the gallbladder) among 96 patients with SLE. The most striking finding in this study was the absence of haematological malignancies. The incidence of malignancy in the series, the age of diagnosis of SLE and neoplasia and the time delay between SLE and malignancy diagnosis was similar to other series. We did not find any clinical or immunological feature that predicted the development of neoplasia. In conclusion, patients with SLE may have the same malignancies as the general population after adjustment for age and sex. There are no predictive indicators for malignancy and immunosuppressive therapy may be a contributing factor.
引用
收藏
页码:377 / 380
页数:4
相关论文
共 27 条
  • [1] ASHERSON RA, 1991, J RHEUMATOL, V18, P277
  • [2] CANCER IN CONNECTIVE-TISSUE DISEASE
    BLACK, KA
    ZILKO, PJ
    DAWKINS, RL
    ARMSTRONG, BK
    MASTAGLIA, GL
    [J]. ARTHRITIS AND RHEUMATISM, 1982, 25 (09): : 1130 - 1133
  • [3] BUSKILA D, 1989, J RHEUMATOL, V16, P993
  • [4] MALIGNANCY IN A SERIES OF 70 PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
    CANOSO, JJ
    COHEN, AS
    [J]. ARTHRITIS AND RHEUMATISM, 1974, 17 (04): : 383 - 390
  • [5] CHUONG JJH, 1982, AM J GASTROENTEROL, V77, P611
  • [6] CYTOTOXIC DRUGS - THEIR CLINICAL-APPLICATION TO THE RHEUMATIC DISEASES
    CLEMENTS, PJ
    DAVIS, J
    [J]. SEMINARS IN ARTHRITIS AND RHEUMATISM, 1986, 15 (04) : 231 - 254
  • [7] THE LONG-TERM CLINICAL OUTCOME OF 56 PATIENTS WITH BIOPSY-PROVEN LUPUS NEPHRITIS FOLLOWED AT A SINGLE CENTER
    DERKSEN, RHWM
    HENE, RJ
    KATER, L
    [J]. LUPUS, 1992, 1 (02) : 97 - 103
  • [8] CYCLOPHOSPHAMIDE TREATMENT OF SYSTEMIC LUPUS-ERYTHEMATOSUS - RISK OF BLADDER-CANCER EXCEEDS BENEFIT
    ELLIOTT, RW
    ESSENHIGH, DM
    MORLEY, AR
    [J]. BRITISH MEDICAL JOURNAL, 1982, 284 (6323) : 1160 - 1161
  • [9] GREEN JA, 1978, LANCET, V2, P753
  • [10] GREENFIELD DI, 1986, J RHEUMATOL, V13, P637