A NEW CHINESE ISOLATE OF HEPATITIS-E VIRUS - COMPARISON WITH STRAINS RECOVERED FROM DIFFERENT GEOGRAPHICAL REGIONS

被引：47

作者：

YIN, SR

PURCELL, RH

EMERSON, SU

机构：

[1] NIAID, INFECT DIS LAB, HEPATITIS VIRUSES SECT, BETHESDA, MD 20892 USA

[2] INST MICROBIOL & EPIDEMIOL, BEIJING, PEOPLES R CHINA

来源：

VIRUS GENES | 1994年 / 9卷 / 01期

关键词：

HEV GENOME; PCR; GENETIC HETEROGENEITY;

D O I：

10.1007/BF01703432

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The full-length cDNA of a new Chinese strain (KS2-87) of Hepatitis E virus (HEV) has been constructed and sequenced. The 5' noncoding region of KS2-87 is 26 nucleotides in length, which is one nucleotide shorter than that of HEV (B1) (Burma) and 23 nucleotides longer than that of HEV (Mexico). Comparison of the nucleotide and amino acid sequences of KS2-87 with all other published HEV sequences showed that KS2-87 was closer to two other Chinese strains (CHT-88, CHT-87) and SAR-55 (Pakistan) than to HEV (B1) and HEV (B2) (Burma) or HEV (Mexico). Comparisons of partial sequences of genes encoding a nonstructural and a structural protein revealed the existence of genetically related groups of HEV within geographical regions, whereas larger nucleotide differences were seen among isolates that were more geographically and epidemiologically distant.

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页码：23 / 32

页数：10

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