VINTAGE REDS AND WHITES - COMBINATORIAL TRANSCRIPTION FACTOR UTILIZATION IN HEMATOPOIETIC DIFFERENTIATION

被引：55

作者：

NESS, SA

ENGEL, JD

机构：

[1] Northwestern University, Department of Biochemistry, Molecular Biology and Cell Biology, Evanston, IL 60208-3500

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 05期

关键词：

D O I：

10.1016/0959-437X(94)90139-T

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pluripotent hematopoietic stem cells can differentiate into a number of distinct specialized cell types; however, no single lineage-specific master regulators have been identified that can activate individual patterns of gene expression. Recent evidence suggests that such lineage determination is regulated by a combinatorial matrix of regulatory proteins with overlapping tissue specificities which cooperate to define individual cell types.

引用

页码：718 / 724

页数：7

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