EXPRESSION OF THE MENKES GENE HOMOLOG IN MOUSE-TISSUES LACK OF EFFECT OF COPPER ON THE MESSENGER-RNA LEVELS

被引：56

作者：

PAYNTER, JA ^{[1
]}

GRIMES, A ^{[1
]}

LOCKHART, P ^{[1
]}

MERCER, JFB ^{[1
]}

机构：

[1] ROYAL CHILDRENS HOSP,MURDOCH INST,SCOBIE & CLAIRE MACKINNON TRACE ELEMENT LAB,PARKVILLE,VIC 3052,AUSTRALIA

来源：

FEBS LETTERS | 1994年 / 351卷 / 02期

基金：

英国医学研究理事会;

关键词：

COPPER TRANSPORT; MENKES DISEASE; MOTTLED MOUSE; RNA BLOT; MESSENGER-RNA;

D O I：

10.1016/0014-5793(94)00868-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The expression of the homologue of the Menkes disease gene (Mnk) in mice was studied using RNA blots. The highest level of expression of the 8.0 kb mRNA was found in placenta, substantial expression was noted in lung, heart, brain, testis and kidney and gut mucosa, but very low levels were found in spleen and adult liver. In fetal liver, the amount of Mnk mRNA is similar to that found in kidney, however, it declines soon after birth. Results with copper-loaded normal mice and mutant mice with genetic defects in copper transport suggested that Mnk mRNA levels are not regulated by tissue copper concentrations.

引用

页码：186 / 190

页数：5

共 20 条

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