PENTAFLUOROPHENYL ESTERS FOR TEMPORARY CARBOXYL GROUP PROTECTION IN SOLID-PHASE SYNTHESIS OF N-LINKED GLYCOPEPTIDES

被引：56

作者：

MELDAL, M

BOCK, K

机构：

[1] Department of Chemistry, Cadsberg Laboratory, DK-2500 Valby, Copenhagen

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(00)97223-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The compound Ac3GlcNAcβ1-NH-Fmoc (3) was synthesized and transformed into the β-glucosyl amine (1) which was subsequently acylated with Fmoc-Asp(Cl)-O-Pfp (5) prepared from the readily available Fmoc-Asp(O-tBu)-O-Pfp (4). The resulting Fmoc-Asn(Ac3GlcNAcβ1-N-)-O-Pfp (6) was used as a building block in the solid phase synthesis of an 11 residue glycopeptide fragment of the enzyme glucoamylase (AMG). © 1990.

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页码：6987 / 6990

页数：4

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