INHIBITION OF HEPATIC GLUCONEOGENESIS BY TRYPTOPHAN-METABOLITES IN RATS AND GUINEA-PIGS

被引：13

作者：

SMITH, SA

ELLIOTT, KRF

POGSON, CI

机构：

[1] Biological Laboratory. University of Kent, Canterbury, CT2 7NJ, Kent

来源：

BIOCHEMICAL PHARMACOLOGY | 1979年 / 28卷 / 14期

关键词：

D O I：

10.1016/0006-2952(79)90196-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Gluconeogenesis from lactate in rat liver cells is inhibited by 0.5 mM kynurenine, picolinate, 5-hydroxytryptamine, indole 3-acetate and tryptamine. In contrast, in guinea pig liver cells only the last three of these are effective; kynurenine and 3-hydroxyanthranilate are activators. Fifty per cent inhibition is achieved by 0.6 mM- and 0.1 mM-indole 3-acetate in the rat and guinea pig respectively, and by 0.12 mM-tryptamine in both species. p-Chlorophenylalanine, MK-486, pargyline and disulfiram do not affect the inhibition of rat hepatocyte gluconeogenesis by tryptophan. The results are discussed in relation to the induction of hypoglycaemia in the rat in vivo by tryptophan. © 1979.

引用

页码：2145 / 2148

页数：4

共 27 条

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[2]

Bergmeyer H.U., 1974, METHOD ENZYMAT AN, VVol. 3., P1196

[3]

ELLIOTT KRF, 1976, BIOCHEM SOC T, V4, P1048

[4] PERMEABILITY OF LIVER-CELL MEMBRANE TO QUINOLINATE [J].