FURTHER EVIDENCE THAT EUGENOL DOES NOT BIND TO DNA INVIVO

被引：18

作者：

PHILLIPS, DH ^{[1
]}

机构：

[1] INST CANC RES,CHESTER BEATTY LABS,LONDON SW3 6JB,ENGLAND

来源：

MUTATION RESEARCH | 1990年 / 245卷 / 01期

基金：

英国医学研究理事会;

关键词：

!sup]32[!/sup]P-Postlabelling; DNA adducts; Eugenol; Mouse liver; Safrole;

D O I：

10.1016/0165-7992(90)90020-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The naturally-occurring alkenylbenzene, eugenol, was examined for its ability to form DNA adducts in the livers of mice that had been treated with up to 10 mg of the compound. No adducts were detected by 32p-postlabelling with a limit of detection of 1 adduct in 109 nucleotides. Under these conditions adducts were readily detected in liver DNA from the structurally-related hepatocarcinogen safrole. © 1990.

引用

页码：23 / 26

页数：4

共 15 条

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