COMPARISON OF CONCURRENT PREGNANCY RATES FOR INVITRO FERTILIZATION EMBRYO TRANSFER, PRONUCLEAR STAGE EMBRYO TRANSFER AND GAMETE INTRAFALLOPIAN TRANSFER

被引：26

作者：

HAMMITT, DG

SYROP, CH

HAHN, SJ

WALKER, DL

BUTKOWSKI, CR

DONOVAN, JF

机构：

[1] Department of Obstetrics and Gynecology, IA City

[2] Department of Urology, University of Iowa Hospitals and Clinics, IA City

来源：

HUMAN REPRODUCTION | 1990年 / 5卷 / 08期

关键词：

GIFT; HUMAN INFERTILITY; IVF; PROST;

D O I：

10.1093/oxfordjournals.humrep.a137226

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Concurrent pregnancy and implantation (sacs/embryos transferred) rates were compared for 84, 77 and 49 cases of in-vitro fertilization-embryo transfer (IVF-ET), pronuclear stage embryo transfer (PROST) and gamete intra-Fallopian transfer (GIFT), respectively. All cases reported occurred during an 18-month interval since the initiation of PROST by our programme. Leuprolide acetate was used with follicle stimulation hormone and human menopausal gonadotrophin for follicular stimulation of all but donor oocyte cases (n = 9). Clinical pregnancy (per transfer) and implantation rates were significantly higher (P < 0.03) for PROST (52.4%, 20.2%) in comparison with IVF-ET (26.9%, 11.4%). Rates for GIFT (48.9%, 18.4%) were not significantly higher (P = 0.10, 0.14) than for IVF-ET. This was probably due to the lower number of GIFT than PROST procedures performed. The total pregnancy rate for GIFT (biochemical, ectopic and clinical combined) was significantly greater (P < 0.05) than for IVF-ET. Pregnancy and implantation rates for PROST and GIFT were similar. These results support the use of PROST rather than IVF-ET for all cases in which the woman has one functional Fallopian tube. Furthermore, to maintain equivalent rates of pregnancy with PROST and GIFT, it is suggested that GIFT should not be used for cases of male-factor infertility without first documenting normal rates of in-vitro fertilization with PROST.

引用

页码：947 / 954

页数：8

共 25 条

[1]

Balmaceda J.P., Gastaldi C., Remohi J., Borrero C., Ord T., Asch R.H., Tubal embryo transfer as a treatment for infertility due to male factor, Fertil. Steril, 50, pp. 476-479, (1988)

[2]

Blackledge D., Matson P., Willcox D., Yovich J., Turner S., Richardson P., Yovich J., Pronuclear stage transfer and modified gamete intrafallopian transfer techniques for oligospermic cases, Med. J. Aust, 145, pp. 173-174, (1986)

[3]

Bongso A., Soon-Chye N., Sathananthan H., Lian N.P., Rauff M., Ratnam S., Improved quality of human embryos when COcultured with human ampullary cells, Hum. Reprod, 4, pp. 706-713, (1989)

[4]

Cohen J., Simons R.F., Edwards R.G., Fehilly C.B., Fishel S.B., Pregnancies following the frozen storage of expanding human blastocysts. J, Vitro Fertil. Embryo Transfer, 2, pp. 59-64, (1985)

[5]

Cramer D.W., Walker A.M., Schiff I., Statistical methods in evaluating the outcome of infertility therapy, Fertil. Steril, 32, pp. 80-86, (1979)

[6]

Davidson A., Vermesh M., Lobo R.A., Paulson R.J., The temporal effects of changes in in vitro fertilization culture media on the one-cell mouse embryo system. J, Vitro Fertil. Embryo Transfer, 5, pp. 149-152, (1988)

[7]

Devroey P., Braeckmans P., Smitz J., Van Waesberghe L., Wisanto A., Steirteghem A., Heytens L., Camus F., Pregnancy after translaparoscopic zygote intrafallopian transfer in a patient with sperm antibodies, Lancet, (1986)

[8]

Devroey P., Staessen C., Camus M., De Grauwe E., Wisanto A., Van Steirteghem A.C., Zygote intrafallopian transfer as a successful treatment for unexplained infertility, Fertil. Steril, 52, pp. 246-249, (1989)

[9]

Hammitt D.G., Bedia E., Rogers P.R., Syrop C.H., Donovan J.F., Williamson R.A., Comparison of motility stimulants for cry o- preserved human semen, Fertil. Steril, 52, pp. 495-502, (1989)

[10]

Hammit D.G., Walker D.L., Syrop C.H., Improved methods for preparation of culture media for in-vitro fertilization and gamete lntra-Fallopian transfer, Hum. Reprod, 5, pp. 457-463, (1990)

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