STUDIES DIRECTED TOWARD THE TOTAL SYNTHESIS OF TETRONOLIDE .2. A STEREOSELECTIVE ROUTE TO THE RACEMIC CYCLOHEXENE SUBUNIT

被引：28

作者：

BOECKMAN, RK

ESTEP, KG

NELSON, SG

WALTERS, MA

机构：

[1] Department of Chemistry University of Rochester, Rochester

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(00)79872-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short stereoselective sequence is described for the preparation of the racemic form of the highly functionalized cyclohexene derivative 2 which comprises the upper segment of tetronolide (1), the aglycone of the antitumor tetrocarcins. A key element of this route is the rapid assembly and intramolecular cycloaddition of the trienyl enol pyruvate 4, which achieves complete control over regiochemistry and good stereochemical control.

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页码：4095 / 4098

页数：4

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