INTERACTION BETWEEN THE LEFT-HANDED Z-DNA AND POLYAMINE - THE CRYSTAL-STRUCTURE OF THE D(CG)3 AND N-(2-AMINOETHYL)-1,4-DIAMINO-BUTANE COMPLEX

被引：30

作者：

OHISHI, H

KUNISAWA, S

VANDERMAREL, G

VANBOOM, JH

RICH, A

WANG, AHJ

TOMITA, K

HAKOSHIMA, T

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,1-6 YAMADA OKA,SUITA,OSAKA 565,JAPAN

[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

[3] LEIDEN UNIV,GORLAEUS LABS,2300 RA LEIDEN,NETHERLANDS

[4] OSAKA UNIV PHARMACEUT SCI,MATSUBARA,OSAKA 580,JAPAN

[5] UNIV ILLINOIS,DEPT PHYSIOL & BIOPHYS,CHAMPAIGN,IL 61820

来源：

FEBS LETTERS | 1991年 / 284卷 / 02期

关键词：

Z-DNA; POLYAMINE; CRYSTAL STRUCTURE; MOLECULAR INTERACTION; MOLECULAR CONFORMATION;

D O I：

10.1016/0014-5793(91)80694-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DNA fragment d(CG)3 was co-crystallized with N-(2-aminoethyl)-1,4-diaminobutane (PA(24)), a chemically synthesized polyamine. The complex crystal contained one polyamine, 3 magnesium cations and one sodium cation per duplex of d(CG)3, and well diffracted the X-ray intensities up to 1.0 angstrom resolution. The d(CG)3 took a left-handed Z-DNA conformation, and the PA(24) molecule electrostatically interacted with the phosphate groups of the d(CG)3 duplex.

引用

页码：238 / 244

页数：7

共 17 条

[1] POLYAMINE METABOLISM .3. URINARY ACETYL POLYAMINES IN HUMAN CANCER [J].