MEASUREMENT OF ADRIAMYCIN (DOXORUBICIN) AND ITS METABOLITES IN HUMAN-PLASMA USING REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND FLUORESCENCE DETECTION

被引：62

作者：

PIERCE, RN

JATLOW, PI

机构：

[1] Department of Laboratory Medicine, Yale University School of Medicine, New Haven

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 164卷 / 04期

关键词：

D O I：

10.1016/S0378-4347(00)81549-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We describe a method for measuring adriamycin and its major metabolite, adriamycinol, in plasma, using reversed-phase high-performance liquid chromatography and fluorescence detection. The lower limit of detection is approximately 1 ng/ml for both compounds; within-day coefficients of variation are 3.6% and 4.4% for adriamycin and adriamycinol, respectively. A slight modification of this procedure also allows measurement of aglycone metabolites. © 1979.

引用

页码：471 / 478

页数：8

共 19 条

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