ISOFLAVONOIDS, GENISTEIN, PSI-TECTORIGENIN, AND OROBOL, INCREASE CYTOPLASMIC FREE CALCIUM IN ISOLATED RAT HEPATOCYTES

被引：25

作者：

TOMONAGA, T

MINE, T

KOJIMA, I

TAIRA, M

HAYASHI, H

ISONO, K

机构：

[1] CHIBA UNIV,SCH MED,DEPT SURG,1-8-1 INOHANA,CHIBA 280,JAPAN

[2] CHIBA UNIV,SCH MED,DEPT BIOCHEM,CHIBA 280,JAPAN

[3] UNIV TOKYO,SCH MED,DEPT INTERNAL MED 4,BUNKYO K,TOKYO 112,JAPAN

[4] GUNMA UNIV,INST ENDOCRINOL,MAEBASHI,GUNMA 371,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 182卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91816-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Isoflavonoid compounds, genistein, psi-tectorigenin and orobol have been implicated as inhibitors of tyrosine-specific protein kinase and phosphatidylinositol turnover. These compounds have been frequently used as a pharmacological tool to assess signal transduction pathways in various cell systems. In the course of analyzing signaling pathways in rat hepatocytes, we obtained an unexpected finding that these compounds transiently increase cytoplasmic free calcium. Since the Ca2+ mobilizing effect was observed in 1 μM calcium containing buffer, the source of the Ca2+ may be intracellular stores. Thus, when interpreting data obtained using these compounds, caution is needed. © 1992.

引用

页码：894 / 899

页数：6

共 14 条

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