DARIERS DISEASE - A FOCAL ABNORMALITY OF CELL-ADHESION

被引：12

作者：

BURGE, SM ^{[1
]}

MILLARD, PR ^{[1
]}

WOJNAROWSKA, F ^{[1
]}

RYAN, TJ ^{[1
]}

机构：

[1] JOHN RADCLIFFE HOSP,DEPT PATHOL,OXFORD OX3 9DU,ENGLAND

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 1990年 / 17卷 / 03期

关键词：

D O I：

10.1111/j.1600-0560.1990.tb00075.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cell adhesion in clinically normal and involved skin in Darier's disease has been investigated using a suction blister technique. We have been unable to detect a subclinical abnormality in cell adhesion which could predispose to the development of acantholytic papules. There may be synthesis of functionally deficient desmosomes, increased breakdown of desmosomes or abnormalities in other adhesion proteins on the surface of the keradnocyte in Darier's disease, but the abnormality in adhesion is focal and restricted to the clinically and histologically abnormal papules. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：160 / 164

页数：5

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