SYNTHESIS OF CYCLIC-PEPTIDES ON SOLID SUPPORT

被引：82

作者：

ROVERO, P

QUARTARA, L

FABBRI, G

机构：

[1] Research Laboratories, A. Menarini Industrie Farmaceutiche Riunite S.r.l., 50131 Firenze

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(00)78806-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We describe a general method for the solid-phase synthesis of cyclic peptides containing an Asp residue in their sequence. Boc-Asp-OFm is linked to PAM resin through the beta-carboxylic function; the linear precursor is then assembled by classical Boc/Benzyl strategy. Cyclization is accomplished by the BOP method; HF deprotection and cleavage afford the cyclic peptide as a single product.

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页码：2639 / 2642

页数：4

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