DESENSITIZATION OF 5-HT1A AUTORECEPTORS BY CHRONIC ADMINISTRATION OF 8-OH-DPAT

被引：40

作者：

KREISS, DS

LUCKI, I

机构：

[1] UNIV PENN,DEPT PSYCHIAT,PHILADELPHIA,PA 19104

[2] UNIV PENN,DEPT PHARMACOL,PHILADELPHIA,PA 19104

来源：

NEUROPHARMACOLOGY | 1992年 / 31卷 / 10期

关键词：

5-HT RELEASE; 5-HT1A RECEPTORS; DESENSITIZATION; MICRODIALYSIS; ANTIDEPRESSANTS; 8-OH-DPAT;

D O I：

10.1016/0028-3908(92)90110-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The function of 5-HT1A autoreceptors was examined by measuring the ability of the 5-HT1A receptor agonist 8-OH-DPAT to reduce 5-HT release in the striatum using in vivo microdialysis. 8-OH-DPAT reduced the release of 5-HT in the striatum. Chronic treatment with 8-OH-DPAT (1.0 mg/kg s.c.) for 7 days, but not 1 day, attenuated the effect of an acute challenge dose of 8-OH-DPAT. The results of the present study indicate that in vivo microdialysis can be used to study the effects of activation of 5-HT1A autoreceptors on 5-HT release and the regulation of 5-HT release by chronic administration of psychoactive drugs.

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页码：1073 / 1076

页数：4

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