THE NATURE AND METABOLISM OF POTENTIALLY AMYLOIDOGENIC CARBOXYL-TERMINAL FRAGMENTS OF THE ALZHEIMER BETA A4-AMYLOID PRECURSOR PROTEIN - SOME TECHNICAL NOTES

被引：11

作者：

GANDY, SE

BUXBAUM, JD

SUZUKI, T

RAMABHADRAN, TV

CAPORASO, GL

NAIRN, AC

GREENGARD, P

机构：

[1] Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021

来源：

NEUROBIOLOGY OF AGING | 1992年 / 13卷 / 05期

关键词：

APP SECRETION; PROTEIN PHOSPHORYLATION; CARBOXYL-TERMINAL FRAGMENTS;

D O I：

10.1016/0197-4580(92)90063-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The proteolytic processing and secretion of APP are regulated by protein phosphorylation, especially via protein kinase C and protein phosphatases 1 and/or 2A. Our studies of these regulatory mechanisms have led us to perform extensive experimentation on the metabolism of APP carboxyl-terminal fragments, using as our system either untransfected, undifferentiated rat pheochromocytoma (PC12) cells or APP-baculovirus infected Sf9 cells. We have not assayed APP fragments for biological activity in either system. However, we have made potentially relevant observations regarding APP carboxyl-terminal fragment trafficking. In this note, we review our published and unpublished data in relation to published reports from other laboratories using related systems.

引用

收藏

页码：601 / 603

页数：3

相关论文

共 12 条

[1] EXPRESSION OF ACTIVE SECRETED FORMS OF HUMAN AMYLOID BETA-PROTEIN PRECURSOR BY RECOMBINANT BACULOVIRUS-INFECTED INSECT CELLS [J].

BHASIN, R ;

VANNOSTRAND, WE ;

SAITOH, T ;

DONETS, MA ;

BARNES, EA ;

QUITSCHKE, WW ;

GOLDGABER, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :10307-10311

[2] PROCESSING OF ALZHEIMER BETA-A4 AMYLOID PRECURSOR PROTEIN - MODULATION BY AGENTS THAT REGULATE PROTEIN-PHOSPHORYLATION [J].

BUXBAUM, JD ;

GANDY, SE ;

CICCHETTI, P ;

EHRLICH, ME ;

CZERNIK, AJ ;

FRACASSO, RP ;

RAMABHADRAN, TV ;

UNTERBECK, AJ ;

GREENGARD, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :6003-6006

[3] CHLOROQUINE INHIBITS INTRACELLULAR DEGRADATION BUT NOT SECRETION OF ALZHEIMER BETA/A4 AMYLOID PRECURSOR PROTEIN [J].

CAPORASO, GL ;

GANDY, SE ;

BUXBAUM, JD ;

GREENGARD, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2252-2256

[4] PROTEIN-PHOSPHORYLATION REGULATES SECRETION OF ALZHEIMER-BETA-A4 AMYLOID PRECURSOR PROTEIN [J].

CAPORASO, GL ;

GANDY, SE ;

BUXBAUM, JD ;

RAMABHADRAN, TV ;

GREENGARD, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (07) :3055-3059

[5] CLEAVAGE OF AMYLOID-BETA PEPTIDE DURING CONSTITUTIVE PROCESSING OF ITS PRECURSOR [J].

ESCH, FS ;

KEIM, PS ;

BEATTIE, EC ;

BLACHER, RW ;

CULWELL, AR ;

OLTERSDORF, T ;

MCCLURE, D ;

WARD, PJ .

SCIENCE, 1990, 248 (4959) :1122-1124

[6] PHOSPHORYLATION OF ALZHEIMER-DISEASE AMYLOID PRECURSOR PEPTIDE BY PROTEIN KINASE-C AND CA-2+/CALMODULIN-DEPENDENT PROTEIN KINASE-II [J].

GANDY, S ;

CZERNIK, AJ ;

GREENGARD, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :6218-6221

[7] ALZHEIMER BETA/A4-AMYLOID PRECURSOR PROTEIN - EVIDENCE FOR PUTATIVE AMYLOIDOGENIC FRAGMENT [J].

GANDY, SE ;

BHASIN, R ;

RAMABHADRAN, TV ;

KOO, EH ;

PRICE, DL ;

GOLDGABER, D ;

GREENGARD, P .

JOURNAL OF NEUROCHEMISTRY, 1992, 58 (01) :383-386

[8]

GANDY SE, 1991, ALZHEIMERS DISEASE : BASIC MECHANISMS, DIAGNOSIS AND THERAPEUTIC STRATEGIES, P155

[9]

GANDY SE, 1992, ALZHEIMERS DISEASE N, P175

[10] PHOSPHORYLATION OF ALZHEIMER AMYLOID PRECURSOR PROTEIN BY PROTEIN-KINASE-C [J].

SUZUKI, T ;

NAIRN, AC ;

GANDY, SE ;

GREENGARD, P .

NEUROSCIENCE, 1992, 48 (04) :755-761