N-OLEOYL-1,2,3,4-TETRAHYDROISOQUINOLINES AS CONFORMATIONALLY RESTRICTED INHIBITORS OF ACYL-COA - CHOLESTEROL ACYL TRANSFERASE (ACAT)

被引：4

作者：

DUGAR, S

CLADER, JW

BURRIER, RE

KOGAN, TP

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81231-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oleoyl-amides of variously substituted 1,2,3,4-tetrahydroisoquinolines were synthesized and assayed for their inhibition of acyl-CoA:cholesterol acyl transferase (ACAT) as conformationally restricted analogs of I and II. These were found to be moderate to good inhibitors of ACAT.

引用

页码：571 / 576

页数：6

共 9 条

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