TUMOR-VIRUSES IN CD30-POSITIVE ANAPLASTIC LARGE-CELL LYMPHOMAS

被引：15

作者：

HERBST, H

STEIN, H

机构：

[1] Institute of Pathology, Klinikum Steglitz, Free University Berlin, 1000

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 9卷 / 4-5期

关键词：

TUMOR VIRUSES; CD30+; ALC LYMPHOMAS;

D O I：

10.3109/10428199309148529

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

CD30+ anaplastic large cell lymphoma (ALCL) represents a novel lymphoma entity at the borderline between Hodgkin's disease and non-Hodgkin's lymphomas. Phenotypic, genotypic, and karyotypic analyses have shown that ALCL are heterogeneous in cellular origin, and may be conceived as malignancies derived from activated, mainly T- or B-lymphoid cells, in some instances with an immature genotype. Epstein-Barr virus genomes and gene products, most notably the transformation-associated latent membrane protein (LMP), have been detected in a proportion of cases, and some cutaneous ALCL proved to harbor complete or incomplete HTLV-1 proviruses. These findings suggest that both EBV and HTLV-1, which are powerful inducers of CD30 expression in lymphoid cells in vitro, may contribute to the pathoetiology of ALCL.

引用

页码：321 / 328

页数：8

共 58 条

[1]

Stein H., Mason D.Y., Gerdes J., O'Connor N., Wainscoat J., Pallesen G., Gatter K., Falini B., Delsol G., Lemke H., Schwarting R., Lennert K., The expression of Hodgkin's disease-associated antigen Ki-1 in reactive and neoplastic lymphoid tissue. Evidence that Reed -Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells, Blood, 66, pp. 848-849, (1985)

[2]

Stein H., Herbst H., Anagnostopoulos I., Niedobitek G., Dallenbach F., Kratzsch H.C., The nature of Hodgkin and Reed-Sternberg cells, their association with EBV, and their relationship to anaplastic large-cell lymphoma, Ann. Oncol., 2, pp. 33-38, (1991)

[3]

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[4]

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[5]

Schwarting R., Gerdes J., Durkop H., Falini B., Pileri S., Stein H., BER-H 2: a new anti-Ki-1 (CD30) monoclonal antibody directed at a formol resistant epitope, Blood, 74, pp. 1678-1689, (1989)

[6]

Durkop H., Latza U., Hummel M., Eitelbach F., Seed B., Stein H., Molecular cloning and expression of a new member of the nev growth factor receptor family that is characteristic for Hodgkin's disease, Cell, 68, pp. 421-427, (1992)

[7]

Stein H., Dienemann D., Dallenbach F., Kruschwitz M., Peripheral T-cell lymphomas, Ann. Oncol., 2, pp. 163-169, (1991)

[8]

Kaudewitz P., Herbst H., Anagnostopoulos I., Eckert F., Braun-Falco O., Stein H., Lymphomatoid papulosis followed by anaplastic large cell lymphoma: immunophenoty-pical and genotypical analysis, Br. J. Dermatol., 124, pp. 465-469, (1991)

[9]

Kaudewitz P., Stein H., Dallenbach F., Eckert F., Bieber K., Burg G., Braun-Falco O., Primary and secondary cutaneous Ki-1<sup>+</sup> (CD30<sup>+</sup>) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical characteristics, Am. J. Pathol., 135, pp. 359-367, (1989)

[10]

Engelhard M., Stein H., von Schilling C., Dallenbach F., Zwingers T., Feller A.C., Stein H., Lennert K., Immunomorphological and clinical characterization of CD30 (Ki-1) positive large cell lymphomas: Identification of three subgroups and their clinical behaviour, Blood, (1992)

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