A statistical evaluation of adsorption data for organic vapors on polar surfaces was conducted. The result was an empirical predictive model based on several physicochemical parameters. Good agreement was found between the experimental values used for the development of the model and the corresponding calculated data. Experimental adsorption data that were not used for the regression analysis as well as data from the literature were predicted with the same accuracy. This was also true for the prediction of vapor adsorption on a bulk water surface, which represents an interesting special case.