CD2 expression in murine B cell lineage

被引：34

作者：

Yagita, Hideo ^{[1
]}

Nakamura, Tetsuya ^{[1
]}

Asakawa, Jun-Ichi ^{[1
]}

Matsuda, Hironori ^{[1
]}

Tansyo, Shigeru ^{[1
]}

Iigo, Yutaka ^{[1
]}

Okumura, Ko ^{[1
]}

机构：

[1] Juntendo Univ, Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 113, Japan

来源：

INTERNATIONAL IMMUNOLOGY | 1989年 / 1卷 / 01期

关键词：

CD2; mouse; B cell differentiation; three colour flow cytometry;

D O I：

10.1093/intimm/1.1.94

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD2 expression in murine B cell lineage was examined by flow cytometric and immunoprecipitation studies with anti-murine CD2 mAb and by Northern blot analysis. Cell surface expression of CD2 was demonstrated on all peripheral B cells and cell lines of B lineage. The murine CD2 transcript of 1.3 kb was detected in these B cells. An Identical glycoprotein of 55-67 KO was precipitated from the lysates of surface radioiodinated thymocytes, splenic T and B cells, T and B lymphomas, RL male 1 and BCL-1, with anti-murine CD2 mAb. The majority of bone marrow B cells and a half of pre-B cells were found to be positive for CD2 expression. These results indicate that murine CD2 Is expressed on B cell lineage at certain differentiation stages.

引用

页码：94 / 98

页数：5

共 33 条

[1] THE T11-GLYCOPROTEIN IS FUNCTIONALLY LINKED TO A CALCIUM-CHANNEL IN PRECURSOR AND MATURE T-LINEAGE CELLS [J].

ALCOVER, A ;

WEISS, MJ ;

DALEY, JF ;

REINHERZ, EL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (08) :2614-2618

[2] FUNCTIONAL AND MOLECULAR ASPECTS OF HUMAN LYMPHOCYTE-T ACTIVATION VIA T3-TI-PATHWAYS AND T11-PATHWAYS [J].

ALCOVER, A ;

RAMARLI, D ;

RICHARDSON, NE ;

CHANG, HC ;

REINHERZ, EL .

IMMUNOLOGICAL REVIEWS, 1987, 95 :5-36

[3]

BLUE ML, 1987, J IMMUNOL, V138, P3108

[4]

BRUCE J, 1981, J IMMUNOL, V127, P2496

[5] B220 - A B-CELL-SPECIFIC MEMBER OF THE T200 GLYCOPROTEIN FAMILY [J].

COFFMAN, RL ;

WEISSMAN, IL .

NATURE, 1981, 289 (5799) :681-683

[6]

DENNING SM, 1987, J IMMUNOL, V139, P2573

[7] EXON INTRON ORGANIZATION AND SEQUENCE COMPARISON OF HUMAN AND MURINE T11 (CD2) GENES [J].

DIAMOND, DJ ;

CLAYTON, LK ;

SAYRE, PH ;

REINHERZ, EL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (05) :1615-1619

[8] NORMAL, AUTOIMMUNE, AND MALIGNANT CD5+ B-CELLS - THE LY-1-B LINEAGE [J].

HAYAKAWA, K ;

HARDY, RR .

ANNUAL REVIEW OF IMMUNOLOGY, 1988, 6 :197-218

[9]

INGRAHAM HA, 1986, J IMMUNOL, V136, P1482

[10] RAPID METHOD FOR ISOLATION OF FUNCTIONAL THYMUS-DERIVED MURINE LYMPHOCYTES [J].

JULIUS, MH ;

SIMPSON, E ;

HERZENBERG, LA .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1973, 3 (10) :645-649

← 1 2 3 4 →