EPILEPTIC TOLERANCE - PRIOR SEIZURES PROTECT AGAINST SEIZURE-INDUCED NEURONAL INJURY

被引：69

作者：

SASAHIRA, M ^{[1
]}

LOWRY, T ^{[1
]}

SIMON, RP ^{[1
]}

GREENBERG, DA ^{[1
]}

机构：

[1] UNIV PITTSBURGH,DEPT NEUROL,PITTSBURGH,PA 15110

来源：

NEUROSCIENCE LETTERS | 1995年 / 185卷 / 02期

关键词：

EXCITOTOXICITY; HEAT SHOCK; HIPPOCAMPUS; SEIZURES; TOLERANCE;

D O I：

10.1016/0304-3940(94)11233-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Heat shock proteins (HSPs) are induced by a variety of insults to the nervous system, including seizures, and may be neuroprotective. If this is so, prior induction of HSPs should decrease neuronal damage upon re-exposure to an injurious stimulus. To test this hypothesis in relation to seizures, bicuculline was given to rats in two sessions, separated by 1, 3, 5 or 7 days; seizure activity was recorded, and HSP-like immunoreactivity and neuronal injury (acid-fuchsin staining) were quantified in the CA3c sector of the hippocampus. Prior seizures conferred a time-dependent protective effect against hippocampal injury induced by subsequent seizures, which may represent 'epileptic tolerance', analogous to the previously described phenomenon of 'ischemic tolerance'.

引用

页码：95 / 98

页数：4

共 14 条

[1] THE DISTRIBUTION OF HYPOGLYCEMIC BRAIN-DAMAGE [J].