ANTIDEPRESSANT DRUGS POTENTIATE SUPPRESSION BY ADENOSINE OF NEURONAL FIRING IN RAT CEREBRAL-CORTEX

被引：26

作者：

STONE, TW ^{[1
]}

TAYLOR, DA ^{[1
]}

机构：

[1] UNIV COLORADO,MED CTR,DEPT PHARMACOL,DENVER,CO 80262

来源：

NEUROSCIENCE LETTERS | 1979年 / 11卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0304-3940(79)90062-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adenosine and AMP (5′-adenosine monophosphate) applied by microionphoresis produced depression of neuronal firing rates in cerebral cortex. A number of antidepressant drugs including examples which are known not to affect noradrenaline uptake systems, potentiated the depressant purine effects. Noradrenaline responses were unaffected or reduced. Purines may therefore be important in the mechanism of action of antidepressant drugs. © 1979.

引用

页码：93 / 97

页数：5

共 24 条

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