BIOCHEMICAL BASIS FOR THE ENHANCED TOXICITY OF DEOXYRIBONUCLEOSIDES TOWARD MALIGNANT HUMAN T-CELL LINES

被引：236

作者：

CARSON, DA ^{[1
]}

KAYE, J ^{[1
]}

MATSUMOTO, S ^{[1
]}

SEEGMILLER, JE ^{[1
]}

THOMPSON, L ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT MED,LA JOLLA,CA 92093

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 05期

关键词：

D O I：

10.1073/pnas.76.5.2430

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.

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页码：2430 / 2433

页数：4

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