IDENTIFICATION AND QUANTITATION OF 1,2-EPOXYBUTENE-3 AS THE PRIMARY METABOLITE OF 1,3-BUTADIENE

被引：75

作者：

MALVOISIN, E ^{[1
]}

LHOEST, G ^{[1
]}

PONCELET, F ^{[1
]}

ROBERFROID, M ^{[1
]}

MERCIER, M ^{[1
]}

机构：

[1] CATHOLIC UNIV LOUVAIN,SCH PHARM,BIOTOXICOL LAB,B-1200 BRUSSELS,BELGIUM

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 178卷 / 02期

关键词：

D O I：

10.1016/S0021-9673(00)92500-7

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

1,3-Butadiene was incubated in the presence of rat liver microsomes supplemented with an NADPH-generating system. One of the major metabolites of butadiene was found to be 1,2-epoxybutene-3, which was analysed by electron-capture gas-liquid chromatography after its derivatization with pentafluorophenylhydrazine. The effects of variation of several incubation parameters and of different pretreatments of the animals on its formation kinetics were evaluated. © 1979.

引用

页码：419 / 425

页数：7

共 12 条

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