BIOSYNTHESIS OF PARA-HYDROXYLATED AROMATICS

被引：11

作者：

SALVO, JJ

MOBLEY, DP

BROWN, DW

CARUSO, LA

YAKE, AP

SPIVACK, JL

DIETRICH, DK

机构：

[1] Biological Sciences Laboratory, GE Research and Development Center, Schenectady, New York, 12301

来源：

BIOTECHNOLOGY PROGRESS | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1021/bp00003a005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A bioconversion process with Aspergillus parasiticus has been developed to enhance p‐hydroxylation activities with respect to aromatic substrates such as m‐terphenyl. Through modified growth conditions, we are improving product concentration, while streamlining fermentation and downstream processing requirements. We routinely carry out biosynthetic conversions with m‐terphenyl at the 300‐L scale and produce over 200 g of 4,4″‐dihydroxy‐m‐terphenyl at a concentration of 0.7 g/L in the fermentation vessel. Copyright © 1990 American Institute of Chemical Engineers (AIChE)

引用

页码：193 / 197

页数：5

共 12 条

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