EFFECTS OF DIETARY SUPPLEMENTATION WITH VITAMIN-E, RIBOFLAVIN AND SELENIUM ON CENTRAL-NERVOUS-SYSTEM OXYGEN-TOXICITY

被引:18
作者
BOADI, WY
THAIRE, L
KEREM, D
YANNAI, S
机构
[1] TECHNION ISRAEL INST TECHNOL,DEPT FOOD ENGN & BIOTECHNOL,IL-32000 HAIFA,ISRAEL
[2] ISRAEL NAVAL HYPERBAR INST,DIV RES,IL-31080 HAIFA,ISRAEL
来源
PHARMACOLOGY & TOXICOLOGY | 1991年 / 68卷 / 02期
关键词
D O I
10.1111/j.1600-0773.1991.tb02039.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We attempted to modify the resistance of rats to hyperbaric oxygen (HBO)-induced central nervous system (CNS) toxicity, by increasing the tissue antioxidant potential through dietary factors. Groups of rats were fed excesses of vitamin E (VIT E) alone or in combinations with riboflavin (RIB), selenium (Se) or both, for 30 days. A control group was maintained on an unsupplemented diet. On the 23rd day animals to be exposed were implanted with chronic electrodes for electrocorticographic (ECoG) recording. Later, each group was divided into two subgroups, of which one was exposed to 4.5 atmospheres absolute (ATA) of 100% oxygen (O2) for 30 min., hereafter referred to as "exposed", noting the time of appearance of first electrical discharge (FED) in their ECoG. The remaining subgroups were left unexposed. Forty-eight hours later, all animals were sacrificed and some of their tissues were analyzed for glutathione (GSH). The GSH level in the liver, brain, lungs and blood of all experimental subgroups were significantly higher than in the control unexposed counterparts. Combinations of RIB and/or Se with VIT E failed to show a greater increase in GSH over VIT E alone. This increase was, however, not accompanied by a meaningful delay in the appearance of FED. Forty-eight hours post-exposure, the brain GSH levels of all exposed subgroups were still lower than the respective pre-exposure levels. Yet, in the treated exposed subgroups the GSH levels observed 48hr after exposure were already higher than in the untreated unexposed controls. Thus, the dietary factors studied may enhance the reparative potential of oxidative tissue injury, but do not afford increased resistance of the brain to HBO, as judged by the respective FED times.
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页码:77 / 82
页数:6
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