CLEAVAGE OF ESTERS USING CARBONATES AND BICARBONATES OF ALKALI-METALS - SYNTHESIS OF THYMOPENTIN

被引：39

作者：

KAESTLE, KL ^{[1
]}

ANWER, MK ^{[1
]}

AUDHYA, TK ^{[1
]}

GOLDSTEIN, G ^{[1
]}

机构：

[1] IMMUNOBIOL RES INST,ANNANDALE,NJ 08801

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 03期

关键词：

D O I：

10.1016/S0040-4039(00)92619-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method for hydrolysis of primary esters using aqueous alkali carbonates or bicarbonates and an alcohol as cosolvent is described. Several peptide esters, including a Cbz-Arg-Lys(Cbz)-Asp(OBzl)-Val-Tyr-OBzl (sequence corresponding to the active site of thymic immunoregulatory hormone, thymopoietin), were hydrolyzed to demonstrate the utility of this method.

引用

页码：327 / 330

页数：4

共 15 条

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