CYTOGENETIC AND FLUORESCENCE IN-SITU HYBRIDIZATION INVESTIGATION OF RING CHROMOSOMES CHARACTERIZING A SPECIFIC PATHOLOGICAL SUBGROUP OF ADIPOSE-TISSUE TUMORS

被引：144

作者：

DALCIN, P

KOOLS, P

SCIOT, R

DEWEVER, I

VANDAMME, B

VANDEVEN, W

VANDENBERGHE, H

机构：

[1] CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,HERESTR 49,B-3000 LOUVAIN,BELGIUM

[2] CATHOLIC UNIV LEUVEN,DEPT PATHOL,B-3000 LOUVAIN,BELGIUM

[3] CATHOLIC UNIV LEUVEN,DEPT ONCOL SURG,B-3000 LOUVAIN,BELGIUM

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 68卷 / 02期

关键词：

D O I：

10.1016/0165-4608(93)90001-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of 184 adipose tissue tumors, 175 lipomas, and nine liposarcomas (LPS) showed the presence of a ring chromosome and/or a long marker chromosome in 10 cases with common histologic features such as atypical stromal cells with or without lipoblasts. In five of the cases, this appeared to be the sole cytogenetic abnormality. Fluorescence in situ hybridization (FISH) analysis with a microclone library specific for chromosome region 12q13-q15 showed extensive staining of the ring and long marker chromosomes, indicating that genetic sequences of this particular region of chromosome 12 are present in these marker chromosomes, most likely in an amplified form.

引用

页码：85 / 90

页数：6

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