MICROSOMAL GLUTATHIONE-S-TRANSFERASE (GST) ISOZYMES IN ASPERGILLUS-OCHRACEUS TS - INDUCTION BY 3-METHYLCHOLANTHRENE

被引：6

作者：

DATTA, J ^{[1
]}

DUTTA, TK ^{[1
]}

SAMANTA, TB ^{[1
]}

机构：

[1] BOSE INST,DEPT MICROBIOL,CALCUTTA 700054,INDIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.2356

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Induction of microsomal glutathione S-transferase isozymes in Aspergillus ochraceus TS is reported. Among the inducers of mammalian drug-metabolising enzymes 3-methylcholanthrene, benzo(a)pyrene and polychlorinated biphenyl enhanced the microsomal GST activity quite considerably. On the other hand phenobarbital, beta-naphthoflavone and trans-stilbene oxide were almost without any effect. To our knowledge this seems to be the first report on induction of microsomal GST in lower eukaryotes. A significant increase (7.9 fold) in GST activity was observed with the cells induced by 3-methylcholanthrene. Moreover, three new GST isozymes were found to be present in 3-methylcholanthrene induced microsomes. The isozymes are basic in nature. The GST isozymes were found to be catalytically distinct from each other. (C) 1994 Academic Press, Inc.

引用

页码：1508 / 1514

页数：7

共 27 条

[1] ACTIVATION AND INHIBITION OF MICROSOMAL GLUTATHIONE TRANSFERASE FROM MOUSE-LIVER [J].