DUAL HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION AND RECOMBINATION IN A DUALLY EXPOSED TRANSFUSION RECIPIENT

被引：106

作者：

DIAZ, RS

SABINO, EC

MAYER, A

MOSLEY, JW

BUSCH, MP

机构：

[1] UNIV CALIF SAN FRANCISCO,IRWIN MEM BLOOD CTR,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143

[3] UNIV SO CALIF,SCH MED,LOS ANGELES,CA 90089

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 06期

关键词：

D O I：

10.1128/JVI.69.6.3273-3281.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied a case in which a 2-month-old premature infant was concurrently transfused with packed erythrocytes from two different human immunodeficiency virus type 1 (HIV-1)-seropositive donors in late 1984. The two donors also each singly infected a second infant. Inspection of sequences from portions of the HIV-1 genomes in each of the two donors showed a close relationship to the strain in their respective singly exposed recipients. Inspection of sequences from the dually exposed recipient provided evidence of an individual simultaneously infected with two distinct HIV-1 strains, as well as recombination of the two strains in vivo.

引用

页码：3273 / 3281

页数：9