EFFECTS OF SUPEROXIDE-DISMUTASE ON NITRIC-OXIDE PRODUCTION DURING REPERFUSION AFTER FOCAL CEREBRAL-ISCHEMIA IN RATS

被引：10

作者：

KUMURA, E

YOSHIMINE, T

KUBO, S

TANAKA, S

HAYAKAWA, T

SHIGA, T

KOSAKA, H

机构：

[1] OSAKA UNIV, SCH MED, DEPT PHYSIOL, SUITA, OSAKA 565, JAPAN

[2] OSAKA UNIV, SCH MED, DEPT NEUROSURG, SUITA, OSAKA 565, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 200卷 / 02期

关键词：

CEREBRAL ISCHEMIA; REPERFUSION; MIDDLE CEREBRAL ARTERY OCCLUSION; NITRIC OXIDE; SUPEROXIDE DISMUTASE; ELECTRON SPIN RESONANCE;

D O I：

10.1016/0304-3940(95)12099-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To assess the interaction of nitric oxide (NO) and superoxide during reperfusion after cerebral ischemia, we studied the dose effects of superoxide dismutase (SOD) on the levels of nitrosyl hemoglobin and plasma nitrite + nitrate which were increased at 30 min reperfusion after 2 h middle cerebral artery occlusion in rats. SOD was administered at 10 min before reperfusion. With 1, 5 and 10 mg/kg of SOD, plasma nitrite + nitrate was not changed, although nitrosyl hemoglobin level was increased with 5 mg/kg SOD. However, plasma nitrite + nitrate level was decreased by 25 mg/kg of SOD. The same amount of apo enzyme was without effect. These results suggest effect of superoxide in the NO level released during reperfusion after cerebral ischemia.

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收藏

页码：137 / 140

页数：4

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