TRANS-4-HYDROXY-3-METHOXYCINNAMIC ACID (FERULIC ACID) INHIBITS THE EFFECT OF ANDROGENS ON THE RAT PROSTATE

被引：8

作者：

SAITO, T ^{[1
]}

NOHNO, T ^{[1
]}

YOSHIDA, H ^{[1
]}

YOKOYA, H ^{[1
]}

机构：

[1] IWATE MED UNIV,SCH DENT,DEPT PHARMACOL,MORIOKA,IWATE,JAPAN

来源：

EXPERIENTIA | 1979年 / 35卷 / 05期

关键词：

D O I：

10.1007/BF01960405

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) antagonized the effect of exogenous androgens on the ventral prostate (VP) in castrated rats as well as the effect of endogenous androgens in intact rats. FA, however, had no effect on the seminal vesicles (SV) and levator ani muscle (LAM), nor oestrogenic effect in female rats and mice. FA did not antagonize the receptor binding of testosterone nor inhibit the conversion of testosterone into 5α-dihydrotestosterone (DHT). © 1979 Birkhäuser Verlag.

引用

页码：696 / 699

页数：4

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