THE NONPHOSPHORYLATED FORM OF RNA POLYMERASE-II PREFERENTIALLY ASSOCIATES WITH THE PREINITIATION COMPLEX

被引：277

作者：

LU, H ^{[1
]}

FLORES, O ^{[1
]}

WEINMANN, R ^{[1
]}

REINBERG, D ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT BIOCHEM,675 HOES LANE,PISCATAWAY,NJ 08854

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 22期

关键词：

D O I：

10.1073/pnas.88.22.10004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The two forms of RNA polymerase II that exist in vivo, phosphorylated (IIO) and nonphosphorylated (IIA), were purified to apparent homogeneity from HeLa cells. The nonphosphorylated form preferentially binds to the preinitiation complex. RNA polymerase II in the complex was converted by a cellular protein kinase to the phosphorylated form.

引用

页码：10004 / 10008

页数：5

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