RAT ANGIOTENSIN-II RECEPTOR - CDNA SEQUENCE AND REGULATION OF THE GENE-EXPRESSION

被引：226

作者：

IWAI, N

YAMANO, Y

CHAKI, S

KONISHI, F

BARDHAN, S

TIBBETTS, C

SASAKI, K

HASEGAWA, M

MATSUDA, Y

INAGAMI, T

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,TOKYO 194,JAPAN

[2] VANDERBILT UNIV,MED CTR,SCH MED,DEPT MICROBIOL,NASHVILLE,TN 37232

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)91982-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleotide and amino acid sequences for rat type I angiotensin II receptor were deduced through molecular cloning and sequence analysis of its complementary DNAs. The rat angiotensin II receptor consists of 359 amino acid residues and has a sequence similar to G protein-coupled receptors. The expression of this receptor gene was detected in the adrenal, liver and kidney by Northern blotting. Sodium deprivation positively modulated the expression of the receptor gene in the adrenal. No detectable change was observed in the expression levels of this receptor gene between spontaneously hypertensive rats and Wistar-Kyoto rats in the tissues examined including the adrenal, brain, kidney and liver. Interestingly the expression of this receptor gene was developmentally regulated. © 1991.

引用

页码：299 / 304

页数：6

共 17 条

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