ENZYME CATALYZED LACTONIZATION OF 3,5 DIHYDROXY ESTERS - ENANTIOSELECTIVE SYNTHESIS OF NATURALLY-OCCURRING 3-HYDROXY-5-DECANOLIDE, (-)-MASSOIALACTONE, AND 3-HYDROXY-5-ICOSANOLIDE

被引：24

作者：

BONINI, C

PUCCI, P

RACIOPPI, R

VIGGIANI, L

机构：

[1] Dipartimento di Chimica, Università della Basilicata, 85100 Potenza

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(00)82308-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Synthesis of optically active (+)-3-hydroxy-5-decanolide, (-)-massoialactone and of the recently isolated 3-hydroxy-5-icosanolide was achieved by enzyme-catalysed lactonization of racemic 3,5 dihydroxy esters with PPL in dry Et2O . Ees vary from 86% up to > 98%.

引用

收藏

页码：29 / 32

页数：4

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