THE STRUCTURAL AND FUNCTIONAL-HETEROGENEITY OF GLUTAMIC-ACID DECARBOXYLASE - A REVIEW

被引：396

作者：

ERLANDER, MG

TOBIN, AJ

机构：

[1] UNIV CALIF LOS ANGELES, DEPT BIOL, LOS ANGELES, CA 90024 USA

[2] UNIV CALIF LOS ANGELES, NEUROSCI PROGRAM, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, INST MOLEC BIOL, LOS ANGELES, CA 90024 USA

[4] UNIV CALIF LOS ANGELES, BRAIN RES INST, LOS ANGELES, CA 90024 USA

来源：

NEUROCHEMICAL RESEARCH | 1991年 / 16卷 / 03期

关键词：

GAD; CDNA; GABA; PYRIDOXAL PHOSPHATE; GLUTAMATE DECARBOXYLASE;

D O I：

10.1007/BF00966084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Studies of the GABA-synthetic enzyme glutamate decarboxylase (glutamic acid decarboxylase; GAD; E.C.4.1.1.15) began in 1951 with the work of Roberts and his colleagues. Since then, many investigators have demonstrated the structural and functional heterogeneity of brain GAD. At least part of this heterogeneity derives from the existence of two GAD genes.

引用

页码：215 / 226

页数：12

共 118 条

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