INSULIN-LIKE GROWTH-FACTORS AND THEIR BINDING-PROTEINS IN HUMAN FOLLICULAR-FLUID

被引：28

作者：

HAMORI, M

BLUM, WF

TOROK, A

STEHLE, R

WAIBEL, E

CLEDON, P

RANKE, MB

机构：

[1] Department of Obstetrics and Gynaecology, D-7400 Tubingen

[2] Children's Hospital, University of Tübingen, D-7400 Tubingen

[3] Department of Obstetrics and Gynaecology, University of Pecs

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 03期

关键词：

INSULIN-LIKE GROWTH FACTORS; INSULIN-LIKE GROWTH FACTOR-BINDING PROTEINS; FOLLICULAR FLUID; IVF;

D O I：

10.1093/oxfordjournals.humrep.a137331

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Increasing evidence suggests that insulin-like growth factors I and II (IGF-I, IGF-II) have a regulatory role in animal granulosa cells. This study was undertaken to investigate the presence of IGF-I and IGF-II, as well as that of their binding proteins (BP), IGFBP-1 and IGFBP-3 in human serum and follicular fluid (FF). Preovulatory FF was obtained from 51 patients undergoing in-vitro fertilization. The IGFBP-1 level was found to be significantly higher (P < 0.01) in FF than in serum, whereas IGF-I and IGFBP-3 values remained markedly lower (P < 0.01) in FF. Serum IGF-II levels were slightly but not significantly elevated compared to values obtained in the FF of patients. A positive correlation (P < 0.001) between individual serum and FF levels was observed only for IGF-I. When a group of poor responders was compared to patients with normal stimulation characteristics, no significant difference was found in either IGF or IGFBP levels in the FF. It is concluded that IGFBP-1 is produced locally, whereas the serum may possibly be the major source of IGF-I. No clear conclusions can be drawn regarding the source of FF IGF-II and IGFBP-3. Neither the absolute level nor the relationship of IGFs to their transport proteins could explain the poor response to ovarian stimulation.

引用

页码：313 / 318

页数：6

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