LOW EXPRESSION OF THE DEOXYCYTIDINE KINASE (DCK) GENE IN A 1-BETA-D-ARABINOFURANOSYLCYTOSINE-RESISTANT HUMAN LEUKEMIC-CELL LINE KY-RA

被引：18

作者：

KOBAYASHI, T

KAKIHARA, T

UCHIYAMA, M

FUKUDA, T

KISHI, K

SHIBATA, A

机构：

[1] Department of Pediatrics, Second Department of Pathology, First Department of Internal Medicine, Niigata University School of Medicine, Niigata 951

来源：

LEUKEMIA & LYMPHOMA | 1994年 / 15卷 / 5-6期

关键词：

1-BETA-D-ARABINOFURANOSYLCYTOSINE; RESISTANCE; DEOXYCYTIDINE KINASE GENE; MUTATION; LEUKEMIC CELL LINE;

D O I：

10.3109/10428199409049755

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Molecular change of the deoxycytidine kinase (dCK) gene in a 1-beta-D-arabinofuranosylcytosine-resistant human leukemic cell line (KY-Ra) was investigated. KY-Ra showed the same restriction pattern of genomic DNA and the same nucleotide sequences of the dCK gene as the parental cell line. However, the amount of deoxycytidine kinase mRNA was markedly decreased in KY-Ra compared to the parental cell line. This is the first report showing that the down regulation of dCK gene expression may be affected by a different mechanism than mutation.

引用

页码：503 / 505

页数：3

共 16 条

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