AN INFECTION-RESISTANT PTFE VASCULAR GRAFT - SPIRAL COILING OF THE GRAFT WITH OFLOXACIN-BONDED PTFE THREAD

被引：13

作者：

OKAHARA, K ^{[1
]}

KAMBAYASHI, J ^{[1
]}

SHIBUYA, T ^{[1
]}

KAWASAKI, T ^{[1
]}

SAKON, M ^{[1
]}

DOHI, Y ^{[1
]}

OKA, Y ^{[1
]}

ITO, S ^{[1
]}

MIYAKE, S ^{[1
]}

机构：

[1] OSAKA UNIV,SCH MED,DEPT SURG 2,SUITA,OSAKA 565,JAPAN

来源：

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY | 1995年 / 9卷 / 04期

关键词：

GRAFT INFECTION; POLYTETRAFLUOROETHYLENE; OFLOXACIN; ANIMAL MODEL;

D O I：

10.1016/S1078-5884(05)80008-5

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Objective: To develop an infection-resistant polytetrafluoroethylene (PTFE) vascular graft for potential clinical use in grafting in sires of bacterial contamination and in replacement of the infected grafts. Setting: Experimental study in rabbits. Materials and methods: An antibiotic ofloxacin (OFLX) was bonded to a sheet of PTFE by impregnation, which was cut and twisted into fine threads. The in-vitro antibacturial activity of OFLX-PTFE thread was determined by measuring the zone of growth inhibition against Escherichia coli. The thread ions spirally coiled around a ridged outerwall PTFE to make the OFLX-PTEE graft. OFLX-PTFE graft or control graft was interposed in tie inferior vena cava (IVC) of rabbits and the entire graft was covered with fibrin containing a fixed number of E. coli. Three or 7 days after the grafting, the grafts with perigraft tissue were harvested and subjected to bacteriological studies. Results: In spite of early phase rapid elution of OFLX, a significant antibacterial activity tons retained for more than 2 weeks. The antibacterial activity of OFLX-PTFE threads implanted in the subcutaneous space of rabbits decreased to 48% after 24 h and to approximately 1% after a week. The swab culture of all the control grafts reins positive, while only one of 13 PTFE-OFLX grafts was positive. The number of viable bacteria in the perigraft-tissue of OFLX-PTFE grafts was remarkably low in comparison with that of control grafts. Thus, the OFLX-PTFE grafts exhibited a marked in-vivo antibacterial activity Conclusion: By a unique method, it was possible to furnish PTFE graft with an excellent infection-resistant property, without affecting the original biological behaviour.

引用

页码：408 / 414

页数：7

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