ACTIVATION OF BKCA CHANNELS IN ACUTELY DISSOCIATED NEURONS FROM THE RAT VENTROMEDIAL HYPOTHALAMUS BY NS-1619

被引：29

作者：

SELLERS, AJ ^{[1
]}

ASHFORD, MLJ ^{[1
]}

机构：

[1] DEPT PHARMACOL,CAMBRIDGE CB2 1QJ,ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1994年 / 113卷 / 03期

关键词：

BKCA CHANNEL; ATP-MODULATED K+ CHANNEL; HYPOTHALAMUS; NS; 1619; POTASSIUM CHANNEL OPENER;

D O I：

10.1111/j.1476-5381.1994.tb17041.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

NS 1619 activates the large-conductance Ca2+-dependent K+ channel (BKca) in membrane patches isolated from rat ventromedial hypothalamic neurones. The activation is concentration dependent, with a maximal effect at less than 30 mu M, reversible and can be inhibited by application of iberiotoxin to the extracellular membrane. NS 1619 does not activate ATP-K+ channels present in the same neurones.

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页码：659 / 661

页数：3

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