EXCRETION AND METABOLISM OF LONG-ACTING NEUROLEPTIC DRUG FLUSPIRILENE IN RAT

被引：14

作者：

HEYKANT.JPP

机构：

[1] Janssen Pharmaceutica, Research Laboratoria Beerse

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 19P1期

关键词：

D O I：

10.1016/0024-3205(69)90154-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Adult male Wistar rats were injected intramuscularly with a 8 mg/kg dose of 3H- and 14C-labelled fluspirilene. The excretion was slow but constant during the first 12 days. The identified metabolites of the urine and faeces indicated oxidative N-dealkylation as the major metabolic pathway. © 1969.

引用

页码：1029 / &

共 8 条

[1]

HAASE H-J, 1968, Nervenarzt, V39, P275

[2]

JANSSEN PAJ, 1969, ARZNEI-FORSCHUNG, V19, P199

[3] A SIMPLIFIED METHOD OF SAMPLE PREPARATION FOR DETERMINATION OF TRITIUM CARBON-14 OR SULFUR-35 IN BLOOD OF TISSUE BY LIQUID SCINTILLATION COUNTING [J].