MODIFICATION OF METOCLOPRAMIDE GLC ASSAY - APPLICATION TO HUMAN BIOLOGICAL SPECIMENS

被引：19

作者：

TAM, YK

AXELSON, JE

ONGLEY, R

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,VANCOUVER V6T 1W5,BC,CANADA

[2] UNIV BRITISH COLUMBIA,FAC MED,VANCOUVER V6T 1W5,BC,CANADA

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 10期

关键词：

Antiemetic agents—metoclopramide; electron‐capture GLC analysis; human plasma and urine; GLC; electron capture—analysis; metoclopramide; Metoclopramide—analysis; electron‐capture GLC;

D O I：

10.1002/jps.2600681015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A modified electron‐capture GLC assay for metoclopramide in human biological specimens is reported. This assay involves the incorporation of a back‐extraction method to remove endogenous contaminants. Its applicability was demonstrated by studying the time course of metoclopramide in plasma and urine from a human subject. The lowest quantifiable metoclopramide concentration in plasma was 7 ng/ml, provided 0.5 ml of plasma was used. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1254 / 1256

页数：3

共 3 条

[1] PHARMACOKINETIC AND CONCENTRATION-EFFECT STUDIES WITH INTRAVENOUS METOCLOPRAMIDE
BATEMAN, DN
KAHN, C
MASHITER, K
DAVIES, DS
[J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1978, 6 (05) : 401 - 407
[2] SENSITIVE ELECTRON-CAPTURE GLC DETERMINATION OF METOCLOPRAMIDE IN BIOLOGICAL-FLUIDS
TAM, YK
AXELSON, JE
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1978, 67 (08) : 1073 - 1077
[3] METOCLOPRAMIDE METABOLISM AND DETERMINATION BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY
TENG, L
BRUCE, RB
DUNNING, LK
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (11) : 1615 - 1618

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