THIN-LAYER CHROMATOGRAPHY OF PROCAINE PENICILLIN G

被引：15

作者：

FOOKS, JR

MATTOK, GL

机构：

[1] Research Laboratories, Food and Drug Directorate, Departmant of National Health and Welfare, Ottawa, Ontario

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 11期

关键词：

Procaine penicillin G‐decomposition products; detection; TLC analysis‐penicillin G; procaine;

D O I：

10.1002/jps.2600581111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chromatographic systems are described which are suitable for the examination of procaine penicillin G preparations which may contain, in addition to procaine and penicillin G, the degradation products p‐aminobenzoic acid, ethyl p‐aminobenzoate, benzylpenicilloic acid, and benzylpenillic acid. Further decomposition of penicillin G occurs when alcoholic solutions are used for spotting the chromtograms, the corresponding alkyl α‐D‐penicilloate being formed, whereas only penicillin G was detected when freshly prepared aqueous solutions were used. However, in aged aqueous solutions the rate of decomposition of penicllin G increased markedly and two new spots, due to benzylpenicilloic acid and benzylpenillic acid, were detected on the chromatogram. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1357 / &

共 13 条

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