4,4'-DIHYDROXYPHENAZONE AS AN URINARY METABOLITE OF PHENAZONE IN DIFFERENT SPECIES INCLUDING MAN

被引：26

作者：

BASSMANN, H ^{[1
]}

BOTTCHER, J ^{[1
]}

SCHUPPEL, R ^{[1
]}

机构：

[1] TECH UNIV BRUNSWICK,INST PHARMAKOL & TOXIKOL,D-3300 BRUNSWICK,FED REP GER

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1979年 / 309卷 / 02期

关键词：

Biotransformation; Drug hydroxylation; Phenazone/antipyrine; Secondary metabolites;

D O I：

10.1007/BF00501230

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

4,4′-Dihydroxyphenazone (4-hydroxy-1-(4′-hydroxyphenyl)-2,3-dimethyl-3-pyrazoline-5-one) was isolated as a metabolite of phenazone (antipyrine) after acid hydrolysis of rat urine. This was characterized and identified by NMR, MS, IR, UV, Fp and ε270. After dosage with phenazone, 4,4′-dihydroxyphenazone is excreted in conjugated form by man, rabbit, guinea pig and rat. In the rat it is further shown, that conjugates of 4,4′-dihydroxyphenazone are formed by glucuronidation as well as by sulfatation. The metabolite seems to add substantially to the overall metabolic pattern of phenazone in these species. © 1979 Springer-Verlag.

引用

页码：203 / 205

页数：3

共 16 条

[1] AARBAKKE J, 1978, ACTA PHARMACOL TOX, V43, P64
[2] NORPHENAZONE, A NEW METABOLITE OF PHENAZONE IN HUMAN URINE
BATY, JD
PRICEEVA.DA
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1973, 25 (01) : 83 - 84
[3] BOTTCHER J, 1979, N-S ARCH PHARMACOL, V307, pR8
[4] BOTTCHER J, UNPUBLISHED
[5] BRODIE BB, 1950, J PHARMACOL EXP THER, V98, P97
[6] FLEISCHER K, UNPUBLISHED
[7] *DIE STOFFWECHSELPRODUKTE DES PYRAMIDONS UND VERWANDTER VERBINDUNGEN BEIM MENSCHEN
HALBERKANN, J
FRETWURST, F
[J]. HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1950, 285 : 97 - 127
[8] HIGNITE CE, 1978, DRUG METAB DISPOS, V6, P288
[9] LAWROW D, 1901, HOPPESEYLERS Z PHYSL, V32, P111
[10] DIE STICKSTOFF-DEMETHYLIERUNG AM PHENAZON (ANTIPYRIN)
SCHUPPEL, R
[J]. NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE, 1966, 255 (01): : 71 - &

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