A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (R)-5,7-O-DIMETHYLEUCOMOL AND (S)-5,7-O-DIMETHYLEUCOMOL

被引：28

作者：

DAVIS, FA

CHEN, BC

机构：

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)97181-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in >96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxycamphoryl)sulfonyl]oxaziridine 9c. © 1990.

引用

页码：6823 / 6826

页数：4

共 22 条

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