A HIGHLY ENANTIOSELECTIVE SYNTHESIS OF (R)-5,7-O-DIMETHYLEUCOMOL AND (S)-5,7-O-DIMETHYLEUCOMOL

被引:28
作者
DAVIS, FA
CHEN, BC
机构
关键词
D O I
10.1016/S0040-4039(00)97181-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in >96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxycamphoryl)sulfonyl]oxaziridine 9c. © 1990.
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页码:6823 / 6826
页数:4
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