REDUCED AND RETRO-REDUCED PEPTIDE ANALOGS-CONFORMATIONS AND ENERGIES

被引：8

作者：

DAUBEROSGUTHORPE, P ^{[1
]}

JONES, DK ^{[1
]}

CAMPBELL, MM ^{[1
]}

SEMPLE, G ^{[1
]}

OSGUTHORPE, DJ ^{[1
]}

机构：

[1] UNIV BATH,DEPT CHEM,BATH BA2 7AY,AVON,ENGLAND

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)94663-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A complete search of the conformational space available to residues with modified amide links was carried out by flexible geometry minimismions of a grid of values of all rotatable bonds. The implications for incorporating these residues in secondary structures were studied. © 1990.

引用

页码：917 / 920

页数：4

共 7 条

[1]

BROWN DW, 1987, TETRAHEDRON LETT, P2171

[2]

CAMPBELL MM, IN PRESS TETRAHEDRON

[3]

CAMPBELL MM, 1989, TETRAHEDRON LETT, P1997

[4] STRUCTURE AND ENERGETICS OF LIGAND-BINDING TO PROTEINS - ESCHERICHIA-COLI DIHYDROFOLATE REDUCTASE TRIMETHOPRIM, A DRUG-RECEPTOR SYSTEM [J].

DAUBEROSGUTHORPE, P ;

ROBERTS, VA ;

OSGUTHORPE, DJ ;

WOLFF, J ;

GENEST, M ;

HAGLER, AT .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1988, 4 (01) :31-47

[5] CONCEPT OF LINEAR MODIFIED RETRO-PEPTIDE STRUCTURES [J].

GOODMAN, M ;

CHOREV, M .

ACCOUNTS OF CHEMICAL RESEARCH, 1979, 12 (01) :1-7

[6] COMPUTER-SIMULATION OF THE CONFORMATIONAL PROPERTIES OF RETRO-INVERSO PEPTIDES .1. EMPIRICAL FORCE-FIELD CALCULATIONS OF RIGID AND FLEXIBLE GEOMETRIES OF N-ACETYLGLYCINE-N'-METHYLAMIDE, BIS(ACETAMIDO) METHANE, AND N,N'-DIMETHYLMALONAMIDE AND THEIR CORRESPONDING C-ALPHA-METHYLATED ANALOGS [J].

STERN, PS ;

CHOREV, M ;

GOODMAN, M ;

HAGLER, AT .

BIOPOLYMERS, 1983, 22 (08) :1885-1900

[7] POTENT NEW INHIBITORS OF HUMAN RENIN [J].

SZELKE, M ;

LECKIE, B ;

HALLETT, A ;

JONES, DM ;

SUEIRAS, J ;

ATRASH, B ;

LEVER, AF .

NATURE, 1982, 299 (5883) :555-557

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