INTRATUMORAL GAMMA-LINOLEIC ACID THERAPY OF HUMAN GLIOMAS

被引：46

作者：

NAIDU, MRC

DAS, UN

KISHAN, A

机构：

[1] NIZAMS INST MED SCI, DEPT NEUROSURG, HYDERABAD 500482, INDIA

[2] NIZAMS INST MED SCI, DEPT MED, HYDERABAD 500482, INDIA

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1992年 / 45卷 / 03期

关键词：

D O I：

10.1016/0952-3278(92)90110-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In vitro and in vivo studies have shown that gamma-linoleic acid (GLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can selectively kill tumor cells. In a clinical trial, the effectiveness of intratumoral administration of GLA in patients with gliomas was studied. Of the 6 patients treated, all showed substantial response to GLA as documented by computerized tomography. There were no acute side-effects due to the therapy. This report demonstrates that intratumoral administration of GLA is a possible approach to the treatment of human glial tumors.

引用

页码：181 / 184

页数：4

共 21 条

[1]

EFFECTS OF DIETARY PRIMROSE OIL ON MAMMARY TUMORIGENESIS INDUCED BY 7,12-DIMETHYLBENZ(A)ANTHRACENE [J].