BARIUM-SULFATE SUSPENSION AS A NEGATIVE ORAL MRI CONTRAST AGENT - INVITRO AND HUMAN OPTIMIZATION STUDIES

被引:35
作者
LI, KCP
TART, RP
FITZSIMMONS, JR
STORM, BL
MAO, JT
ROLFES, RJ
机构
[1] Department of Radiology, University of Florida, College of Medicine, Gainesville
关键词
MAGNETIC RESONANCE; CONTRAST ENHANCEMENT; GASTROINTESTINAL TRACT; BARIUM;
D O I
10.1016/0730-725X(91)90002-4
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In vitro proton spectroscopy with line-width measurements and MR imaging were performed on various concentrations of commercially available single contrast (SC), double contrast, oral and rectal barium sulfate suspensions, as well as potassium sulfate, barium chloride, barium hydroxide, and 97% pure barium sulfate suspensions. Approximately 500 ml of 20%, 40%, 60%, and 70% w/w suspensions of SC oral barium sulfate suspensions were administered to four normal volunteers, respectively, and MR images were obtained at both 1.5 T and 0.15 T. Subsequently, 500 ml of 60% w/w suspensions of SC oral barium sulfate suspensions were administered to five normal volunteers and imaged at 1.5 T. All of the inert suspensions produced line-width broadening but the SC oral barium sulfate suspension at 50% and 70% stayed in suspension even after hours of standing undisturbed. As much as 80% of the small bowel and the entire colon were well visualized using the combination of 60% or 70% w/w SC barium sulfate suspensions with SE 550/22 and FISP pulse sequences. The effect was less at 0.15 T and also with the SE 2000/45/90 pulse sequences. We conclude that barium sulfate suspensions are useful as oral MRI contrast agents.
引用
收藏
页码:141 / 150
页数:10
相关论文
共 19 条
[1]  
Parikh, Mezrich, Deuterated barium sulfate as an oral MRI contrast agent, Proceedings of Annual Meeting of Society of Magnetic Resonance in Medicine, (1988)
[2]  
Burnett, Goldstein, Wolf, Sen, Mamourian, The oral administration of MnCl<sub>2</sub>: A potential alternative to IV injection for tissue contrast enhancement, Magn. Reson. Imaging, 2, pp. 307-314, (1984)
[3]  
Mamourian, Burnett, Goldstein, Wolf, Kressel, Baum, Proton relaxation enhancement in tissue due to ingested manganese chloride: Time course and dose response in the rat, Physiol. Chem. Phys. Med. NMR, 16, pp. 123-128, (1984)
[4]  
Wesbey, Brasch, Goldberg, Engelstad, Moss, Dilute oral iron solutions as gastrointestinal contrast agents for magnetic resonance imaging: Initial clinical experience, Magn. Reson. Imaging, 3, pp. 57-64, (1985)
[5]  
Runge, Stewart, Clanton, Jones, Lukehart, Partain, James, Potential oral and intravenous paramagnetic contrast agents, Radiology, 147, pp. 789-791, (1983)
[6]  
Laniado, Kornmesser, Hamm, Clauss, Weinmann, Felix, MR imaging of the gastrointestinal tract: Value of Gd-DTPA, AJR, 150, pp. 817-821, (1988)
[7]  
Kaminsky, Gogoll, Laniado, Et al., Gadolinium-DTPA as a positive contrast agent in abdominal MR imaging, Proceedings of Annual Meeting of Society of Magnetic Resonance in Medicine, (1989)
[8]  
Widder, Edelman, Grief, Monda, Magnetite albumin suspension: A superparamagnetic oral MR contrast agent, AJR, 149, pp. 839-843, (1987)
[9]  
Hahn, Stark, Sanjay, Lewis, Wittenberg, Ferrucci, Ferrite particles for bowel contrast in MR imaging: Design issues and feasibility studies, Radiology, 164, pp. 37-41, (1987)
[10]  
Hahn, Stark, Saini, Et al., Clinical evaluation of superparamagnetic iron oxide particles as a gastrointestinal contrast agent for MR imaging, Radiology, 173, P, (1989)