URINARY LEUKOTRIENE-E4 LEVELS AFTER ALLERGEN AND EXERCISE CHALLENGE IN BRONCHIAL-ASTHMA

被引：95

作者：

SMITH, CM ^{[1
]}

CHRISTIE, PE ^{[1
]}

HAWKSWORTH, RJ ^{[1
]}

THIEN, F ^{[1
]}

LEE, TH ^{[1
]}

机构：

[1] GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,4TH FLOOR,HUNTS HOUSE,LONDON SE1 9RT,ENGLAND

来源：

AMERICAN REVIEW OF RESPIRATORY DISEASE | 1991年 / 144卷 / 06期

关键词：

D O I：

10.1164/ajrccm/144.6.1411

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Urinary leukotriene E4 (LTE4) concentrations were measured in six asthmatic subjects after treadmill exercise, and in five asthmatic subjects after allergen challenge. Exercise and allergen challenge produced a 42 +/- 18% (mean +/- SD) and 22 +/- 8% fall in FEV1, respectively. The baseline concentration of urinary LTE4 in subjects challenged with exercise was 64 (27 to 150) pg/mg creatinine (geometric mean and 95% confidence interval), and in those challenged with allergen it was 36 (23 to 59) pg/mg creatinine. Urinary LTE4 concentrations did not change significantly in the 24 h after exercise. In contrast, there was a mean 4-fold increase In urinary LTE4 during the 3 h after allergen challenge.

引用

页码：1411 / 1413

页数：3

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